Semaglutide Dosage Chart: Wegovy, Ozempic & Rybelsus

Semaglutide doesn't have one dose chart — it has several, because the same molecule is sold as three different products with three different ceilings, plus compounded versions. Wegovy (weight management) climbs to 2.4 mg, Ozempic (type 2 diabetes) stops at 2 mg, and Rybelsus (oral) runs on its own milligram scale entirely. Picking the wrong chart is the most common semaglutide dosing mistake.

This is a reference page. Find your product in the overview, then read its section.

Semaglutide Products at a Glance

All four are semaglutide. The ceilings differ because each product was studied and approved on its own — you can't move a dose from one column to another.

Wegovy Dose Chart (Weight Management)

Wegovy is the weight-management form and the one most people mean by "semaglutide dosage for weight loss." It uses a five-step titration to the 2.4 mg maintenance dose:

You reach the full 2.4 mg dose at week 17 at the earliest. In the STEP 1 trial, 2.4 mg weekly produced an average of about 15% body-weight loss at 68 weeks. If 2.4 mg is hard to tolerate, 1.7 mg is an accepted alternate maintenance dose — your prescriber can hold you there rather than pushing to the ceiling. The injection mechanics are in how to inject Wegovy, and cost — which differs sharply from Ozempic — is covered in the Wegovy cost guide.

Missed dose (Wegovy): if your next scheduled dose is more than 2 days (48 hours) away, take the missed dose as soon as you can. If it's less than 2 days away, skip it. If you miss doses for more than 2 weeks, contact your prescriber — you may need to restart at a lower dose and re-titrate.

Ozempic Dose Chart (Type 2 Diabetes)

Ozempic shares the first three steps with Wegovy but stops at 2 mg: 0.25 mg (weeks 1-4) → 0.5 mg → 1 mg → 2 mg, each step at least 4 weeks. It's approved for type 2 diabetes and cardiovascular risk reduction, not weight management. Because the pen mechanics and missed-dose rules differ slightly, Ozempic has its own full breakdown — see the Ozempic dose chart for the titration table, pen strengths, and the Ozempic-vs-Wegovy ceiling in detail.

Rybelsus Dose Chart (Oral Semaglutide)

Rybelsus is the only oral semaglutide, and its milligram numbers are not comparable to the injectables — oral bioavailability is low, so the doses look much higher:

The 3 mg starting dose exists only to improve tolerability; it's not a treatment dose. After 30 days you move to 7 mg, and if more control is needed after at least another 30 days, to the 14 mg maximum.

How you take it matters as much as the dose. Rybelsus must be taken on an empty stomach when you first wake up, with no more than 4 oz (120 mL) of plain water, and you must wait at least 30 minutes before eating, drinking anything else, or taking other oral medications. Take it with food or too much water and absorption drops sharply. If you're weighing oral against injectable semaglutide, Rybelsus vs Ozempic covers the bioavailability and efficacy trade-offs.

Compounded Semaglutide Dosing

Compounded semaglutide uses the same 0.25 mg once-weekly starting dose and typically follows either the Wegovy or Ozempic target ladder, depending on what your provider prescribes. What changes is the delivery: a multi-dose vial drawn in units on a syringe rather than a fixed-dose pen, with concentration that varies by pharmacy.

Two practical points:

• Confirm the conversion. Get the milligram-per-unit math from your provider or the vial label before your first draw, so your units match the intended milligrams. The vial mechanics and unit math are the same as any reconstituted injectable — see the peptide reconstitution guide.
• Titrate the same way. A vial doesn't change the biology. Start at 0.25 mg, hold four weeks, step up. Note that demand for compounded semaglutide has been declining as brand supply normalizes — confirm your pharmacy and product are current.

Why the Ceilings Differ

The single most useful thing to remember: 2 mg is not the same as 2.4 mg, and 14 mg oral is not 14 mg injected. Wegovy's higher 2.4 mg ceiling reflects the weight-management trials; Ozempic's 2 mg reflects the diabetes trials; Rybelsus's milligram scale reflects oral bioavailability. They're the same drug, but the products are not interchangeable at the dose level. If your goal is weight loss specifically, the relevant ladder is Wegovy's — and which product you're on is a prescriber decision, not a dose you self-adjust. The shared mechanism is covered in the semaglutide guide.

Managing Side Effects During Titration

Across all forms, GI side effects flare for a week or two at each dose increase, then settle. Nausea is the most common; smaller meals, less fat, and hydration help. If a step stays rough after two to three weeks, tell your prescriber — extending time at the current dose (or holding at 1.7 mg for Wegovy) is the studied lever, not pushing through. The fuller breakdown by frequency, and the signals that mean "call your provider," is in semaglutide side effects.

Why Tracking Titration Matters

Titration is exactly the kind of thing that's hard to hold in your head: the dose changes on a schedule, side effects shift at each level, and the decision to step up or hold depends on data you only have if you recorded it. Worth logging at each step:

• Injection (or tablet) date and dose — confirms you're on schedule and how long you've held the current level
• Injection site — supports rotation (see the GLP-1 injection site rotation guide)
• GI symptoms and severity — shows your prescriber the adaptation curve at each dose
• Appetite and weight trend — the signal you're titrating toward

Done Dose tracks all of this in one place, including your dose-level history — so when it's time to decide whether to move from 1.7 mg to 2.4 mg, you're reading a record instead of guessing. Set it up in under a minute.

For the other major GLP-1 and how it doses, compare with the tirzepatide dose chart.