Best HRT Tracker Apps for Hormone Replacement Therapy (2026)

HRT spans a wide range of medications, routes, and clinical contexts — menopausal hormone therapy, gender-affirming hormone therapy, post-surgical hormone replacement. What they share is complexity: most HRT regimens involve multiple medications, non-standard schedules, and often injectable components that general medication apps handle poorly. Here are five apps that serve different parts of the HRT landscape, with honest assessments of each.

Quick Reference: Top 3 HRT Tracker Picks

1. DoneDose -- Best for injectable HRT (estradiol valerate, testosterone cypionate). Visual body map for site rotation, flexible scheduling, and multi-medication support for mixed-route regimens.
2. Transcapsule -- Best for gender-affirming HRT specifically. Designed for the trans community with transition-focused tracking and milestone features.
3. Hormona -- Best for menopause-related HRT. Cycle tracking, symptom logging, and hormone therapy monitoring designed for perimenopausal and menopausal women.

Feature Comparison

Individual App Reviews

DoneDose

DoneDose works for any injectable medication, and that universality is its strength for HRT users. If you're on injectable estradiol valerate every five days, DoneDose handles the non-standard schedule natively — no workaround needed for intervals that don't align with a weekly pattern. If you're on testosterone cypionate for masculinizing HRT, the same injection tracking and site rotation features that serve TRT users serve you equally well.

The visual body map for injection site rotation is the standout feature. HRT injections are long-term — often lifelong — which makes proper rotation a genuine clinical concern. The body map shows where you've injected, how long each site has been resting, and which sites are ready. Over months and years, this visual history catches rotation drift that memory-based tracking misses.

Multi-medication support matters for HRT because regimens rarely involve just one drug. Injectable estradiol plus oral progesterone plus spironolactone is a common feminizing stack. Injectable testosterone plus potential ancillaries is standard for masculinizing HRT. DoneDose tracks all of it with appropriate scheduling for each medication.

Honest weakness: DoneDose is not specifically designed for HRT. It doesn't include transition-specific features like milestone tracking, symptom logging oriented toward hormonal changes, or educational content about hormone therapy. It's a medication tracker that handles injectables exceptionally well — the HRT context is something you bring, not something the app provides.

Transcapsule

Transcapsule is built specifically for the transgender community and gender-affirming hormone therapy. The app understands the HRT journey in a way that general trackers don't — it includes features for tracking transition milestones, logging changes over time, and connecting with a community of people on similar paths. For many users, the emotional and social context of HRT matters as much as the dose logging, and Transcapsule honors that.

Medication tracking covers the basics: reminders, dose logging, and a history of your HRT medications. The app handles both oral and injectable medications and understands common HRT regimens.

Honest weakness: The injection tracking specifically is basic compared to DoneDose. No visual body map for site rotation, limited site history, and the dose logging is functional but not detailed. If your primary concern is precise injection tracking and rotation for injectable estradiol or testosterone, Transcapsule's strengths lie elsewhere. It's a transition companion that includes medication tracking, not a medication tracker designed for injections.

Hormona

Hormona approaches HRT from the menopause and reproductive health angle. The app combines cycle tracking with hormone therapy monitoring, which makes it particularly suited for perimenopausal women starting HRT or adjusting their regimen based on symptoms. Symptom logging is detailed — hot flashes, sleep disruption, mood changes — and seeing these symptoms charted alongside your HRT schedule provides genuinely useful data for provider conversations.

The educational content around menopause and hormone therapy is well-produced and evidence-based. For women navigating the confusing landscape of menopausal HRT options, Hormona provides context that most medication trackers don't.

Honest weakness: No injection tracking to speak of. Hormona is designed for oral and transdermal HRT — pills, patches, creams. If your HRT regimen includes injectable estradiol (which some women prefer for more stable levels), Hormona doesn't have the features to track that well. No site rotation, no injectable-specific scheduling, and no IM/SubQ distinction.

Regimen

Regimen's protocol management approach works well for structured HRT regimens. You define your full HRT protocol — medications, doses, schedule, administration routes — and Regimen tracks your adherence against that framework. The protocol-first design keeps your entire regimen visible and organized, which is helpful when you're managing three or four medications on different schedules.

The app handles injectable medications with basic site notation and supports both SubQ and IM logging. Cross-platform availability (iOS and Android) is an advantage over some competitors in this space.

Honest weakness: Not HRT-specific. Regimen doesn't include symptom tracking, hormonal change monitoring, or any context related to hormone therapy specifically. Site rotation is basic — general area tracking rather than visual body-map precision. It's a solid protocol manager that happens to work for HRT, not a purpose-built HRT tool.

Medisafe

Medisafe is the workhorse of the general medication tracker world and handles the oral components of HRT regimens well. Its notification system is best-in-class — reliable, customizable, and persistent without being obnoxious. If your HRT is entirely oral (estradiol tablets, progesterone capsules, spironolactone), Medisafe is a legitimate option with a mature, polished interface.

The app supports large medication lists and handles complex scheduling, including medications taken at different times, with food, or on specific days. Caregiver sharing features are well-implemented.

Honest weakness: No injection site rotation. No IM/SubQ distinction. Medisafe treats an estradiol valerate injection the same as a daily pill — a dose is a dose. For the injection components of HRT, this gap is meaningful. The app excels at the pill portion of your regimen but provides no value-add for the injectable portion beyond basic reminders.

How We Evaluated

HRT encompasses diverse clinical contexts, so we evaluated each app across the features that matter most regardless of the specific hormone therapy type:

• Injectable medication support. Many HRT regimens include injectable components. We evaluated how well each app handles injection tracking, site rotation, and non-standard dosing intervals.
• Multi-medication management. HRT rarely involves a single medication. We assessed how each app handles regimens with three to five medications across different routes and schedules.
• Scheduling flexibility. HRT schedules vary widely — daily pills, every-5-day injections, twice-daily medications, weekly injections. We looked for apps that handle all of these natively.
• Symptom tracking. For menopause-related HRT especially, tracking symptoms alongside medication adherence provides clinically valuable data. We evaluated whether each app includes relevant symptom logging.
• Inclusivity and context. HRT serves different populations with different needs. We assessed whether each app serves its intended users respectfully and with appropriate clinical context.
• Long-term usability. HRT is typically ongoing for years or decades. We considered whether each app builds useful historical records and remains practical for long-term use.

For injectable HRT users specifically, our injection site rotation guide compares rotation tracking in detail. The TRT injection log guide covers testosterone injection tracking practices that apply to all testosterone HRT, regardless of clinical context.

Choosing the Right App for Your HRT Type

The "best" HRT tracker depends heavily on what kind of HRT you're on and what you need from the app:

If your HRT includes injectables — estradiol valerate, testosterone cypionate, or any other injectable hormone — DoneDose provides the strongest injection tracking and site rotation features. Pair it with whatever symptom tracking works for you, whether that's Hormona, a journal, or notes within DoneDose.

If you're on gender-affirming HRT and want an app that understands your specific context, Transcapsule offers a community and milestone tracking that no general app matches. For the injection tracking portion specifically, DoneDose complements Transcapsule well.

If you're on menopausal HRT that's entirely oral or transdermal, Hormona or Medisafe will serve you well. Hormona adds symptom context that Medisafe doesn't. Medisafe adds better notification reliability and cross-platform support.

If your HRT is a complex multi-medication protocol and you want everything in one structured system, Regimen provides the best protocol-level organization.

Frequently Asked Questions

What is the best app for tracking HRT?

It depends on your HRT type. For injectable hormone therapy (estradiol valerate, testosterone cypionate), DoneDose offers the best injection site rotation and dose logging. Transcapsule is specifically designed for gender-affirming HRT with transition-focused features. Hormona is built for menopause and cycle-related HRT. Medisafe works well if your HRT is entirely oral or topical.

Can I use a general medication tracker for HRT?

For basic reminders, yes. But HRT often involves multiple medications on different schedules — injectable estradiol every five days, daily oral progesterone, twice-daily spironolactone. General trackers handle this poorly because they weren't designed for the scheduling complexity or the injection tracking that HRT requires.

Do I need injection site rotation for HRT injections?

Yes. Whether you're injecting estradiol valerate or testosterone cypionate, proper site rotation prevents lipohypertrophy, scar tissue, and absorption inconsistencies. HRT is typically a long-term or lifelong therapy, which makes rotation discipline even more important over time.

Is there an HRT tracker app specifically for transgender hormone therapy?

Transcapsule is specifically designed for gender-affirming HRT with features oriented toward transition milestones, medication tracking, and community support. DoneDose is a strong alternative for the injection tracking component, though it's not transition-specific.

Can I track both injectable and oral HRT medications in one app?

DoneDose and Medisafe both support mixed-route medication tracking. DoneDose handles this particularly well because it was designed for injectable medications while also supporting oral and topical medications with appropriate scheduling for each.

Done Dose tracks injectable HRT with the precision long-term hormone therapy demands. Visual site rotation, flexible scheduling for any injection interval, and multi-medication support for your full regimen — estradiol, testosterone, progesterone, ancillaries, all in one place. Your injection history becomes a record that serves you and your prescriber for years to come. See how Done Dose handles HRT tracking.